Abstract
Blood glucose monitoring is very important for the prevention, control and treatment of diabetes. However, the application of existing glucose sensors is limited by poor bio-compatibility, complex readout approaches, slow response and complex fabrication. Most significantly, most sensors cannot meet the necessities of high-sensitivity and large-range simultaneously. Herein, we proposed a high-selective microprobe glucose optical fiber biosensor based on surface plasmon resonance (SPR), which might not solely bring high-sensitivity detection, however additionally cover the concentration range of human glucose. The experimental results demonstrate that the detection range reaches 0-200 mg/dL, and the maximum glucose concentration sensitivity reaches 0.1688 nm/(mg/dL). The limit of detection (LOD) was calculated to be 4 mg/dL. Furthermore, it is verified that the sensor resists the interference of sodium ions, potassium ions, sucrose, chitosan. The designed sensor with the advantage of high-selectivity, high-sensitivity and large-range has great potential for real-time, continuous glucose monitoring in the biological medicine fields.
Published Version
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