Abstract
L1 in tumor vasculature.
Highlights
Angiogenesis is a pre-requisite for the growth and the metastatic dissemination of solid tumors
To address the question of whether L1 plays any role in tumor vessels, we combined the genetic inactivation of endothelial L1 in Tie2Cre;L1floxed mice with a syngeneic, orthotopic model of pancreatic carcinoma
Our data showed that L1 exerts a massive regulation of the endothelial transcriptome, and that such a regulation involves factors that play a prominent role in angiogenesis, such as vascular endothelial growth factor (VEGF)-A, VEGF-C and Dll4, as well as molecules that contribute to endothelial-mesenchymal transition, such as Zeb-1, Zeb-2, N-cadherin, S100A4, etc
Summary
Angiogenesis is a pre-requisite for the growth and the metastatic dissemination of solid tumors. Several studies have shown the aberrant expression of L1 in cancer cells, where it promotes invasion and metastasis and its level correlates with poor prognosis [3]. Screening a panel of different tumor types, we observed that L1 is expressed in cancer-associated vasculature, while no or very little expression was detected in normal vessels [4, 5].
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