Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test.

Takumi Nagasawa,Hirotaka Ishigaki,Takao Kimura,Suguru Hiramoto,Itsumi Suda,Yoshifumi Shoho,Akihiro Yoshida,Osamu Araki,Masami Murakami,Katsuhiko Tsunekawa,Kazumi Ushiki

doi:10.3390/nu13072191

Takumi Nagasawa, Hirotaka Ishigaki + Show 9 more

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https://doi.org/10.3390/nu13072191

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Journal: Nutrients	Publication Date: Jun 25, 2021
Citations: 10	License type: CC BY 4.0

Affiliation: Gunma University, Gunma University Hospital

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In a recent study, we showed that konjac glucomannan (KGM) inhibits rice gruel-induced postprandial increases in plasma glucose and insulin levels. To extend this research, we investigated the effects of KGM addition to rice gruel on pre- and postprandial concentrations of circulating lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), hepatic triglyceride lipase (HTGL), free fatty acids (FFA), and triglycerides (TG). A total of 13 Japanese men, without diabetes, dyslipidemia, or gastrointestinal diseases, interchangeably ingested rice gruel containing no KGM (0%G), rice gruel supplemented with 0.4% KGM (0.4%G), and rice gruel supplemented with 0.8% KGM (0.8%G), every Sunday for 3 weeks. Blood samples were obtained at baseline and at 30, 60, and 120 min after ingestion to measure the abovementioned lipid parameters. Lipid parameters showed small, but significant, changes. Significant reductions were found in circulating FFA levels among all participants. Circulating TG levels significantly declined at 30 min and then remained nearly constant in the 0.8%G group but exhibited no significant difference in the 0%G and 0.4%G groups. Although circulating levels of LPL and GPIHBP1 significantly decreased in the 0%G and 0.4%G groups, they increased at 120 min in the 0.8%G group. Participants in the 0%G and 0.4%G groups showed significant decreases in circulating HTGL levels, which was not observed in the 0.8%G group. Our results demonstrate the novel pleiotropic effects of KGM. Supplementation of rice gruel with KGM powder led to TG reduction accompanied by LPL and GPIHBP1 elevation and HTGL stabilization, thereby attenuating TG metabolism.

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Konjac glucomannan (KGM) is a rich source of soluble fiber that contains almost no calories [1]
This study investigated the effects of KGM supplementation on postprandial changes in circulating levels of lipid parameters, including TG, free fatty acids (FFA), lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), and hepatic triglyceride lipase (HTGL), among middle-aged Japanese participants
Our results show that the intake of rice gruel supplemented with KGM powder led to a decrease in circulating TG levels, elevated LPL/GPIHBP1 levels, and stable HTGL concentrations

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Konjac glucomannan (KGM) is a rich source of soluble fiber that contains almost no calories [1]. Previous studies have shown that KGM offers major health benefits—such as lowering blood glucose, cholesterol, triglyceride (TG), lowering blood pressure levels, and reducing body weight by promoting intestinal activity and boosting immune function in humans [1,2,3,4,5,6,7]. In these investigations, participants habitually ingested KGM every day for 8 weeks [1,2,3,4,5,6,7]. Due to its characteristic of becoming viscous in the gastrointestinal tract, KGM acts as a barrier to the absorption of sugars and nutrients [1,2,3,4,5,6,7]

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