Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells.

Phil June Park,Eun-Gyung Cho

doi:10.3390/ijms20081859

Phil June Park, Eun-Gyung Cho

Open Access

https://doi.org/10.3390/ijms20081859

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Abstract

Adiponectin (APN), released mainly from adipose tissue, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity. A recent study showed that human hair follicles express APN receptors and the presence of APN-mediated hair growth signaling, thereby suggesting that APN is a potent hair growth-promoting adipokine. Previously, kojyl cinnamate ester derivatives (KCEDs) were synthesized in our institute as new anti-aging or adiponectin-/adipogenesis-inducing compounds. Here, we tested the activity of these derivatives to induce endogenous APN secretion. Among the derivatives, KCED-1 and KCED-2 showed improved activity in inducing APN mRNA expression, secretion of APN protein, and adipogenesis in human subcutaneous fat cells (hSCFs) when compared with the effects of Seletinoid G, a verified APN inducer. When human follicular dermal papilla cells were treated with the culture supernatant of KCED-1- or KCED-2-treated hSCFs, the mRNA expression of APN-induced hair growth factors such as insulin-like growth factor, hepatocyte growth factor, and vascular endothelial growth factor was upregulated compared with that in the control. Taken together, our study shows that among kojyl cinnamate ester derivatives, KCED-1, KCED-2, as well as Seletinoid G are effective inducers of endogenous APN production in subcutaneous fat tissues, which may in turn contribute to the promotion of hair growth in the human scalp.

Highlights

Adipose tissue, an active metabolic and endocrine organ, plays important roles in physiological and pathological processes by secreting a variety of soluble factors [1]
Levels were prone to be decreased weakly but relatively by the treatments of kojyl cinnamate ester derivatives (KCEDs)-1, KCED-2-treated, or 50% of SG-treated human subcutaneous fat cells (hSCFs) conditioned media compared with control treatment. These results suggest that SG, kojyl cinnamate ester derivative-1 (KCED-1), or KCED-2-treated hSCF media could contribute to hair growth promotion in vitro
We demonstrated that the kojyl cinnamate ester derivatives including SG, KCED-1, and KCED-2 induce APN production in vitro and stimulate adipogenesis in hSCFs

Summary

Introduction

An active metabolic and endocrine organ, plays important roles in physiological and pathological processes by secreting a variety of soluble factors [1]. Subcutaneous fat, a white adipose tissue beneath the skin dermis and the largest adipose tissue in the body, is involved in regulating body temperature and skin elasticity in normal states. Its dysregulation is associated with abnormal states including obesity, which has impacts on skin physiology, skin manifestations, dermatologic diseases, and lipodystrophy [2,3,4], indicating the important functions of adipocytes or adipocyte-derived factors in skin pathophysiology. Adiponectin (APN), along with leptin, is a key hormone that is exclusively released from white adipocytes including those in subcutaneous adipose tissue and is involved in regulating glucose levels, lipid metabolism, and insulin sensitivity [5,6]. Dermatol. 2007, 56, 901–916, quiz 917–920. [CrossRef] [PubMed]

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