Abstract

BackgroundPre-Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP) are key to preventing sexual transmission of HIV, whose sexual partners are at high risk of acquiring HIV.We aimed to determine the factors associated with PrEP and PEP’s knowledge as secondary prevention among people living with HIV/AIDS.MethodCross-sectional analytical study carried out among people living with HIV/AIDS treated at five specialized services in the city of Ribeirão Preto, São Paulo, Brazil. Data were collected from July 2016 to July 2017. Individual interviews were conducted. We used multivariable logistic regression to determine factors associated with knowing PrEP and PEP.ResultsOf the 397 participants, 140 (35.26%) were heterosexual women aged 40 to 49 years (36.2%).Participants with less than 11 years of study (adjusted odds: 0.29; 95% CI: 0.13–0.60); who did not have a low viral load or did not know their viral load (adjusted odds: 0.29; 95% CI: 0.09–0.83) and those with casual partners (adjusted odds: 0.29; 95% CI: 0.09–0.83) were less likely to know about the PrEP. MSM (adjusted odds: 2.88; 95% CI: 1.59–5.3) and those who used alcohol during sexual intercourse (adjusted odds: 1.7; 95% CI: 1.0–2.8) were more likely to know about the PEP.ConclusionsThe knowledge about PEP and PrEP is low in Brazil. This may undermine secondary prevention efforts. Educational interventions to raise awareness of these prevention methods are needed among people living with HIV and who have HIV-negative sexual partners.

Highlights

  • Pre-Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP) are key to preventing sexual transmission of Human Immunodeficiency Virus (HIV), whose sexual partners are at high risk of acquiring HIV

  • men who have sex with men (MSM) and those who used alcohol during sexual intercourse were more likely to know about the PEP

  • Educational interventions to raise awareness of these prevention methods are needed among people living with HIV and who have HIV-negative sexual partners

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Summary

Introduction

Pre-Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP) are key to preventing sexual transmission of HIV, whose sexual partners are at high risk of acquiring HIV. We aimed to determine the factors associated with PrEP and PEP’s knowledge as secondary prevention among people living with HIV/AIDS. Infection caused by the Human Immunodeficiency Virus (HIV), almost five decades after notification of the first cases, remains a worldwide public health problem, despite all the advances achieved in the treatment and expansion of prevention strategies. It is estimated that approximately 37.9 million people live with HIV worldwide by the end of 2018 [1]. Since 1996, the country has offered antiretroviral treatment through the Unified Health System (SUS) for People Living with HIV (PLHIV) and was one of the pioneer countries among low and middle incomes. New infection rates have remained persistently high over the past decade, with an estimated 48,000 new

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