Abstract
Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as cellular protection against ROS, inflammation, carcinogenesis, atherosclerosis, heart diseases, and metabolism. In mammals, six PRDX members have been identified and are subdivided into three subfamilies: typical 2-Cys (PRDX1, PRDX2, PRDX3, and PRDX4), atypical 2-Cys (PRDX5), and 1-Cys (PRDX6) subfamilies. Knockout mouse models of PRDXs have been developed to investigate their in vivo roles. This review presents an overview of the knockout mouse models of PRDXs with emphases on the biological and physiological changes of these model mice.
Highlights
The peroxiredoxin (PRDX) family has peroxidase activity to remove peroxides, including hydrogen peroxide (H2 O2 ), organic hydroperoxides, and peroxynitrite [1,2]
This review presents an overview of the knockout mouse models of PRDXs with emphases on the biological and physiological changes of these model mice
PRDXs are classified into three subfamilies based on the number and location of the active cysteine residues and the type of disulfide bonds produced during the catalytic reaction (Figure 1) [4,5,6,7,8]
Summary
The peroxiredoxin (PRDX) family has peroxidase activity to remove peroxides, including hydrogen peroxide (H2 O2 ), organic hydroperoxides, and peroxynitrite [1,2]. PRDXs are classified into three subfamilies (typical 2-Cys, atypical 2-Cys, and 1-Cys) based on the number and location of the active cysteine residues and the type of disulfide bonds produced during the catalytic reaction (Figure 1) [4,5,6,7,8]. Peroxides oxidize the conserved peroxidatic cysteine (CP ) in typical 2-Cys PRDXs, and the oxidized cysteine sulfenic acid residue in a subunit forms an intermolecular disulfide bond with the resolving cysteine (CR ) in the other subunit [7]. Peroxidatic cysteine; CR,mouse resolving cysteine; GSH, glutathione; peroxide; Trx, thioredoxin. Prdx-knockout mouse models and focuses on the biological and physiological changes of these model information that is hard to obtain from other experiments. Properties of Prdx-knockout mouse models and focuses on the biological and physiological changes
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