Abstract
Objective The clinical data of 4 cases of Klinefelter syndrome (KS) complicated with diabetes mellitus admitted to our hospital since 2016 were retrospectively analyzed in order to improve the understanding of the disease. Methods According to the records of inpatient and outpatient visits, the medical history and laboratory examination results of 4 KS patients with diabetes mellitus were summarized and analyzed. Results They were (43.0±12.7) years old, and were diagnosed with KS when they were (41.5 ± 13.9) years old. They were (1.67 ± 0.07) m tall. Their body mass index (BMI) was (22.05 ± 1.87) kg/m2. After the treatment, they got significant improvement in blood glucose and sex hormone levels (P 0.05). Conclusion Clinically, the early diagnosis rate of KS is low. Married adult male with infertility is an important clue for the diagnosis of KS. In addition to controlling blood glucose and androgen replacement therapy, risk factors such as dyslipidemia and fatty liver should be actively dealt with in KS patients with diabetes mellitus. Key words: Klinefelter syndrome; Diabetes mellitus; Karyotype
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