Klebsiella pneumoniae, an important Uropathogen: Characteristics and antimicrobial susceptibility pattern at Prof. Dr. I.G.N.G. Ngoerah general hospital, period February – September 2020

Abstract

Background: Klebsiella pneumoniae (K. pneumoniae) caused urinary tract infections (UTIs) are the rise all over the world and have emerged as a significant issue for public health. K. pneumoniae's characteristics as a uropathogen and their antimicrobial susceptibility pattern will be examined in this study at a tertiary care hospital. Method: The Clinical Microbiology laboratory at Prof. Dr. I. G. N. G. Ngoerah General Hospital was where this descriptive retrospective cross-sectional study was carried out. All urine cultures were included in this study, and Vitek-2 Compact (BioMerieux®) was used to identify and test for bacterial susceptibility. Data were collected over a period February-September 2020. Result: The results show 60 isolates K. pneumoniae was isolated from urine specimens. This study included outpatients and inpatients of both sex with different age. The male (51.7%) has the highest rate of infection compared to the female (48.3%), with adult patients (76.7%) and child patients (23.3%), whereas Extended-Spectrum β-Lactamase (ESBL) producing K. pneumoniae (53.3%) and non-ESBL (46.7%). The antimicrobial susceptibility test showed that K. pneumoniae mostly sensitive to meropenem (96.7%) and amikacin (93.3%) and resistance to nitrofurantoin (73.3%) and ciprofloxacin (65%). Conclusion: This study found that the percentage of ESBL producing K. pneumoniae was 53.3%. Antibiotics that are often used for the treatment of UTIs, ciprofloxacin and trimethoprim/sulfamethoxazole, have high resistance rate of 65% and 51.7%, respectively. In addition, Ertapenem, meropenem, and amikacin had the highest antimicrobial sensitivity rates.