Abstract
Kiwi fruit has long been believed to be beneficial to human health due to its numerous biological actions; however the pharmacological mechanisms associated with these benefits are incompletely understood. In the present study, the effects of ‘Halla Gold’ (Actinidia chinensis var.), a new kiwifruit cultivar bred by the Jeju Rural Development Administration (RDA), on chronic insulin-induced insulin resistance in L6 skeletal muscle cells was investigated. Chronic insulin reduced phosphorylation of Akt and GSK-3α/β, and increased phosphorylation of glycogen synthase (GS). Furthermore, glucose consumption and glucose transporter 4 (Glut4) translocation to the plasma membrane were inhibited. However, ‘Halla Gold’ extract (HGE) increased phosphorylation of Akt and GSK-3α/β concomitantly with decreased phosphorylation of GS. Moreover, HGE improved insulin-stimulated glucose consumption by facilitating Glut4 translocation and this stimulation was suppressed by inhibition of PI3 kinase. Together, our data suggest that ‘Halla Gold’ extract abolishes chronic insulin-induced insulin resistance through the PI3K/Akt pathway.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
