Abstract
A two-compartment reversible model describing the occurrence of pharmacologic effect in goldfish as a function of drug concentration in the bathing solution was examined. The derived expressions were applied to 4-aminoantipyrine-induced overturn. The rate constants of absorption and exsorption for this drug were 4.0 × 10−4 hr.−1 and 7.8 × 10−3 hr.−1, respectively. The theoretical drug concentration in the fish body necessary for overturn was 19.5 mg. %, which agrees with the experimental results. The mathematical relationships and experimental data demonstrate that a critical concentration is necessary in the fish body before a pharmacologic response will occur. At low drug concentration in the bathing solution, the reciprocal time-drug concentration plots will be hyperbolic rather than linear. The results of this study suggest that 4-aminoantipyrine-induced overturn in the goldfish is absorption rate limited.
Published Version
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