Kinetics Aspects in Design and Release of Nasal Drug Delivery Systems

Abstract

The traditional school of Indian medicine includes a sort of nasal therapy known as Nasya karma. There is a lot of recent interest in using the nasal route for administering difficult medications including tiny polar compounds, vaccines, hormones, peptides, and proteins. Nasal drug molecules are highly suited for systemic distribution and the absence of hepatic first-pass metabolism. Vaccination through the nose is thought to be a straightforward and economical method with improved patient compliance, and it may also provide immunity at numerous distant mucosal locations. Microparticle, nanoparticle, and liposomal nasal vaccination delivery technologies are now in development and show protection in animal models. Both pharmacokinetics & pharmacodynamics of nasal administration devices have been studied in-vivo by a number of different research organizations. The purpose of this review was to summarise these studies and bring attention to the work done on nasal-based formulations to better treat conditions like epilepsy, schizophrenia, and neurodegenerative diseases.