Abstract
Oxidation kinetics of inositol (INOS) by cerium(IV) has been studied spectrophotometrically in perchlorate medium at fixed ionic strength and temperature. The reaction showed a first order dependence with respect to [Ce(IV)] and less than unit order kinetics in both [H<sup>+</sup>] and [INOS]. Increasing both ionic strength and dielectric constant of the reaction medium increased the oxidation rate. Addition of Ce(III) product had no any significant effect on the oxidation rate. The oxidation product of inositol was identified by both spectroscopic and chemical tools as inosose. A plausible mechanistic scheme for oxidation reaction has been proposed and the rate law associated with the reaction mechanism was derived. The activation parameters of the second order rate constant were calculated and discussed.
Highlights
Inositol is a six membered cyclic polyol, which is synthesized in the kidneys [1]
Inositol and some of its derivatives used as the basis for some signaling and secondary messenger molecules [2,3] which are involved in insulin signal transduction, gene expression, breakdown of fats and reducing blood cholesterol [4]
Inositol at constant [H+], ionic strength and temperature were allowed to react for 24 h for completion of the oxidation reaction
Summary
Inositol is a six membered cyclic polyol, which is synthesized in the kidneys [1]. Inositol and some of its derivatives used as the basis for some signaling and secondary messenger molecules [2,3] which are involved in insulin signal transduction, gene expression, breakdown of fats and reducing blood cholesterol [4]. Cerium(IV) is a significant single electron oxidant in acid media [10,11,12,13,14,15,16,17,18,19,20,21,22,23]. In perchlorate medium, this oxidant has rarely been employed [21,22], probably due to presence of dimers and polymers of cerium (IV) in such medium [22]. Oxidation reactions by cerium(IV) in perchloric acid solutions proceed much faster than those in sulfuric acid ones
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