Abstract
The inhibition of horseradish peroxidase activity by N-phosphonomethyl-glycine, an active ingredient in the most extensively used glyphosate-based herbicide (Roundup) in agricultural applications worldwide, was investigated. It has been shown that N-phosphonomethyl-glycine inhibits the activity of peroxidase from horseradish roots. This inhibition is of a competitive nature, the value of Ki = 0.1004 mM. The Michaelis constant (Km = 0.1776 mM) and herbicide concentration (I50 of Roundup = 0.302 mM) were determined. The results demonstrate that N-phosphonomethyl-glycine can suppress the activity of the antioxidant system, and in warm-blooded organisms it may cause the accumulation of free radicals, thereby contributing to expanding knowledge of biological targets Roundup is applied to.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
