Abstract
Simple, accurate and precise spectrophotometic methods for quantitative determination of four drugs viz., Levofloxacin (LEV), Moxifloxacin (MOX), Pseudo Ephidrine (PSE), Torsemide (TOR) have been developed based on oxidation of the drugs by alk.KMnO4. Kinetics of the oxidation reaction is followed spectrophotometrically, as one of the reaction product, Mn(VI), absorbed at 610 nm. Initial rate and fixed time method are used for the construction of calibration curves Beer's law is obeyed in the range 6.25-37.5 µg ml -1 for LEV; 5-30 µg ml -1 for MOX; 6.25-37.5 µg ml -1 for PSE and 2.5-15 µg ml -1 for TOR. Recovery studies using pure samples and pharmulations in the Beer's Law limits have been carried out. Excellent recoveries indicate the methods are accurate and precise. The methods have been validated in terms of ICH guidelines. Statistical analysis in terms of student's t- test and variance F- tests demonstrate high accuracy and precision and suggest the methods can be applied in bulk drug and pharmaceutical industries. Keywords: Spectrophotometry, Determination, Drugs, KMnO4. Torsemide chemically 3-(4-((3-methylphenyl) amino) pyridin-3-yl)sulfonyl-1-propan-2-ylurea (Fig.1 d), is a loop diuretic mainly used in the management of edema associated withcongestive heart failure. It is also used at low doses for the management of hypertension (24,25).Hydrotropy phenomenon is considered as a unique technique by which solubility for sparinglysoluble solute under normal conditions increase in the several folds(26).
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