Abstract
Rapid electron transfer from electron adducts of pyrimidine nucleotides dCMP, TMP and UMP to sensitizers of riboflavin (RF), flavin adenine dinucleotide (FAD) and chloranil (CHL) were studied using the techniques of pulse radiolysis. Both spectroscopic and kinetic analyses showed that the transient absorption spectra of pyrimidine electron adducts formed at first, and then were replaced by those of radical anions of RF, FAD and CHL after several microseconds of electron beam pulse, which indicated that electron transfer from electron adducts of pyrimidines to RF, FAD and CHL occurred. From buildup kinetics of sensitizer radical anions, a series of rate constants for electron transfer are determined respectively. RF and FAD can capture electron from pyrimidine electron adducts induced in irradiated cell, which would reduce possible repair of damaged targets due to the inhibition of charge recombination of radical ion pair. Thereby RF and FAD might play the role of radio-sensitizer in DNA damage process.
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