Abstract
Kinetic modeling and the rise of systems pharmacology
Highlights
The paper by Gadkar, Lu, and colleagues in this issue of the Journal of Lipid Research offers an opportunity to comment on the intersection of two different philosophies in kinetic modeling that are just beginning to join forces in the practical worlds of disease modeling and systems pharmacology
In many fields of biology, kinetic modeling is a new topic; students often think that the idea of applying engineering analysis to biological systems originated in 2002 when Hiroaki Kitano coined the phrase, “systems biology,” as an umbrella for large scale mechanistic modeling of biomedical systems [1, 2]
Berman and Levy and their students attacked the pivotal questions of plasma lipoprotein metabolism
Summary
The paper by Gadkar, Lu, and colleagues in this issue of the Journal of Lipid Research offers an opportunity to comment on the intersection of two different philosophies in kinetic modeling that are just beginning to join forces in the practical worlds of disease modeling and systems pharmacology. His vision was simple; linear algebra, linear differential equations, and computers comprised the ideal set of tools to formulate models of biological systems and test them against tracer kinetic data [3].
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