Abstract
Food allergy (FA) is an adverse immune response to certain innocent food. It is estimated about 2% to 6% of the general population suffer from FA. Symptoms of a food allergic reaction may involve the gastrointestinal tract or/and other organs. The gut microbiota plays a critical role in diet-induced health problems. Whether the changes in the composition of the intestinal microbiota regulate allergic responses to food remains poorly understood. Thus, we created an FA animal model, sequenced the V4-V5 regions of 16S rRNA genes to characterize the genera abundance of gut microbiota. The results showed that mice under FA condition showed different gut bacterial structures. Diverse distribution of the bacterial species was identified between FA and control groups. FA altered the components of intestinal Microbiota in mice. The dysbiosis of the gut metagenome correlated with the development of the FA.
Highlights
Food allergy (FA) is an IgE-mediated allergic response in the body; the pathogenesis if unclear
We found that abundant infiltration of mast cells and eosinophils in the intestinal mucosa of the FA group than that of the CK group (Figure 1C)
The results demonstrated that the gut microbiota was changed tremendously under FA condition, including the increasing of the diversity, the changes in the bacterial species distribution and the enrichment of some bacterial genera
Summary
Food allergy (FA) is an IgE-mediated allergic response in the body; the pathogenesis if unclear. The symptoms of FA mainly occur in the intestine; and occur in other organs, such as in the skin, airway and kidney. The research in FA was advanced rapidly in the recent years, the mechanism of Th2 polarization is still to be further investigated. Several FA mouse models have been published. Among the materials used in the development of FA model, microbial products, such as cholera toxin, Staphylococcal enterotoxin B, were used as adjuvants in the sensitization. The fact implicate that the alteration of amounts of microbes or the composition may be related to the pathogenesis of FA; this is to be further investigated
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