Abstract
In different applications, pharmaceutical products are widely distributed and frequently released into the environment. The adsorption of Mebeverine hydrochloride (MB.HCl) on chitosan polymer was studied under certain conditions. The Adsorption Isotherms can be well defined using the Freundlich and Temkin equations. The pH of the solution significantly influences the adsorption potential of chitosan, the adsorption of chitosan increased from the initial pH of 1.1 and then decreased over the (2-10) pH range. Adsorption is sensitive to the change in ion strength, indicating that electrostatic attraction is an important mechanism for the sorption process. Adsorption of chitosan to MB.HCl is defined as endothermic adsorption by enthalpy change (ΔH). The value of the (ΔG) is negative at all the temperatures studied, which suggests the spontaneous trend to adsorb MB.HCl to chitosan. The value of (ΔG) decreased when the temperature rose from 5°C to 25°C, indicating higher adsorption of MB.HCl at an increased temperature. The positive value of (ΔS) represents chitosan’s attraction to drugs as well as that randomness on its solid-solution interface.
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