Abstract
In this study we investigated the anticancer effects of Kimchi (DV) extract obtained from Baechu kimchi fermented and stored in a kimchi refrigerator for 21 days. The DV kimchi extract contained higher levels of ornithine compared with control kimchi (DS) extract obtained from standard storage condition. The DV kimchi significantly inhibited the proliferation of both AGS (human, gastric adenocarcinoma) and HL‐60 (human, acute promyelocytic leukemia) cell lines. The DV kimchi extract treatment lead to increased apoptosis and decreased mitochondrial transmembrane potential in the cultured HL‐60 leukemia cells. In addition, the treatments resulted in increased expression of the p53 gene in cultured AGS gastric adenocarcinoma cells. On the other hand, the DS kimchi treatments showed relatively a small effect on the cancer cell growth prevention, apoptosis, and mitochondrial transmembrane potential at the similar concentration ranges of kimchi extract. These results suggest that, the consumption of DV kimchi could be more beneficial in promoting apoptosis and retarding the proliferation of cancer cells compared to the DS kimchi. This research was funded by WiniaMando Inc.
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