Abstract
Introduction: Kikuchi - Fujimoto disease (KFD), also known as Histiocytic necrotizing lymphadenitis is a benign, uncommon, self-limited disease of unknown etiology. Young females are primarily affected and it manifests primarily as cervical lymphadenopathy with tenderness at times. Kikuchi and Fujimoto, way back in 1972, reported it from Japan, independently and simultaneously, as a type of lymphadenitis associated with numerous histiocytes and extensive nuclear debris. The present study aims to study the key cytomorphological features of KFD along with its clinicopathological correlation. Materials and Methods: This present study was carried out in a tertiary care hospital for a period of one year. The cases that were diagnosed as KFD on Fine needle aspiration cytology (FNAC) and whose follow up histopathology was confirmatory were included in the present study. Papanicolaou stain (PAP stain), Hematoxylin and eosin stain (H&E), and May-Grunwald Giemsa stain (MGG stain) was done on smears. Following cytological features were evaluated; cellularity, crescentic histiocytes, plasmocytoid monocytes, karyorrhectic debris and intra and extra cytoplasm apoptotic bodies. Result: Females in the age group of 31-40 years were most commonly affected with cervical lymphadenopathy as the presenting feature. The most common clinical diagnosis rendered by clinicians was tuberculosis. Karyorrhexis, crescentic histiocytes and plasmacytoid monocytes were the key cytological features. Conclusion: This study emphasizes on the key cytological features of the rare entity of KFD and its clinicopathological correlation. Knowledge and timely diagnosis of this rare entity avoids unnecessary surgical intervention and helps in timely management. Keywords: Cervical lymphadenopathy, Crescentic histiocytes, Karyorrhexis.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call