Abstract
KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer.
Highlights
Pancreatic cancer is a highly fatal disease in which mortality is closely related to the incidence [1]
High expression of KIF20B was found in pancreatic cancer (n 179) contrasted with adjacent normal tissues (n 171, Figure 1(a)). 178 patients with pancreatic adenocarcinoma were divided into two groups (89 patients with high expression of KIF20B and 89 patients with low expression of KIF20B ) in this database
Pancreatic cancer is a poor prognosis disease, and five-year survival of which is as low as 2% in some countries, despite the surgical technique is improving [30]
Summary
Pancreatic cancer is a highly fatal disease in which mortality is closely related to the incidence [1]. Most pancreatic cancer patients remain asymptomatic until the disease is advanced. Pancreatic cancer is one of the leading causes of fatal disease in cancer across the world [2]. E main types of pancreatic cancer are adenocarcinoma (85%) and endocrine carcinoma (less than 5%) [2,3,4]. According to the cancer statistics in 2018, about 55,440 people suffered from pancreatic cancer, and pancreatic cancer causes 44,330 deaths [5]. In 2017, there were 53,670 patients with pancreatic cancer and 43,090 patients died because of pancreatic cancer [6]. Pancreatic cancer was 11th common cancer in
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