Abstract
Summary1. The alkaline phosphatase activity of the rat kidney, which reflects principally the enzyme content of the proximal convoluted tubules, could not be changed from the normal by varying the amount of glucose for reabsorption over periods of 6 to 12 hours.2. The kidneys of rats suffering from chronic alloxan diabetes as a rule contained less than normal amounts of alkaline phosphatase. The lowest values were obtained when first examined one week after the dose of alloxan, but recovery of a normal content was not complete when the last examination was performed after 42 days. The proximal convoluted tubule epithelium that had regenerated after the alloxan injury was thus observed to be slow in acquiring its normal enzyme content.
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