KIBRA rs17070145 polymorphism and resting EEG spectral activity: Biomarkers for reduced risk of Alzheimer’s disease

Abstract

Event Abstract Back to Event KIBRA rs17070145 polymorphism and resting EEG spectral activity: Biomarkers for reduced risk of Alzheimer’s disease Genevieve Z. Steiner1, 2*, Francesca Fernandez-Enright3, 4, Robert J. Barry2 and Emma Barkus2 1 Western Sydney University, National Institute of Complementary Medicine, Australia 2 University of Wollongong, Centre for Psychophysics, Psychophysiology, and Psychopharmacology, Australia 3 University of Wollongong, Illawarra Health and Medical Research Institute, Australia 4 Schizophrenia Research Institute, Australia KIBRA (KIdney/BRAin) is a cytoplasmic protein encoded by the WWC1/KIBRA gene and is primarily expressed in memory-related regions of the brain (hippocampus, cortex). A functional Single Nucleotide Polymorphism (SNP) (rs17070145) within KIBRA has been associated with memory performance and Alzheimer’s disease risk. Recent work has demonstrated that KIBRA T allele carriers have significantly better episodic memory scores than non-carriers, and a reduced risk of Alzheimer’s disease. Identifying EEG biomarkers of KIBRA T allele carrier status may further our understanding of the impact of this SNP on neural networks, and early risk factors for Alzheimer’s disease. Sixty-one young adults had their resting EEG activity continuously recorded from 30 scalp sites for 2 minutes with their eyes open. Participants also completed a computerised neurocognitive test battery (CogState), and provided a saliva sample for DNA extraction and analysis. Mean EEG band power was computed across the 2-minute block for delta, theta, alpha, beta, and gamma. The genotyping for KIBRA rs17070145 polymorphism was performed using Sequenom MassARRAY® genotyping assay. KIBRA T allele carrier status was compared with EEG activity and CogState scores. Delta, theta, alpha, beta, and gamma bands showed the expected eyes-open resting state topographic distributions. KIBRA T allele carrier status was related to delta and theta only, with greater delta power at the vertex and midline parietal sites, and reduced theta power centrally on the left for T allele carriers. Increased delta levels also improved reaction time in a sustained attention task independent of KIBRA T allele carrier status. Results indicate that delta and theta power are modulated by KIBRA. Given the role of the hippocampal-cortical memory system in the generation of slow wave activity, further work should explore whether KIBRA affects this neural network during cognitive tasks, and whether this activity is associated with Alzheimer’s disease risk. Keywords: Electroencephalography, Delta Rhythm, Theta Rhythm, KIBRA, single nucleotide polymorphism (SNP), Alzheimer's disease, Memory Conference: ASP2015 - 25th Annual Conference of the Australasian Society for Psychophysiology, Sydney, Australia, 2 Dec - 4 Dec, 2015. Presentation Type: Oral Presentation Topic: Psychophysiology Citation: Steiner GZ, Fernandez-Enright F, Barry RJ and Barkus E (2015). KIBRA rs17070145 polymorphism and resting EEG spectral activity: Biomarkers for reduced risk of Alzheimer’s disease. Conference Abstract: ASP2015 - 25th Annual Conference of the Australasian Society for Psychophysiology. doi: 10.3389/conf.fnhum.2015.219.00039 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Oct 2015; Published Online: 30 Nov 2015. * Correspondence: Dr. Genevieve Z Steiner, Western Sydney University, National Institute of Complementary Medicine, Penrith, NSW, 2751, Australia, G.Steiner@westernsydney.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Genevieve Z Steiner Francesca Fernandez-Enright Robert J Barry Emma Barkus Google Genevieve Z Steiner Francesca Fernandez-Enright Robert J Barry Emma Barkus Google Scholar Genevieve Z Steiner Francesca Fernandez-Enright Robert J Barry Emma Barkus PubMed Genevieve Z Steiner Francesca Fernandez-Enright Robert J Barry Emma Barkus Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.