Abstract
To the Editor: Before 2007, two human polyomaviruses were known to infect humans: BK virus and JC virus (1,2). Recently, 2 novel polyomaviruses, KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV), were identified in the respiratory secretions of children with signs of acute respiratory signs (3,4); little evidence exists to suggest that these viruses are causative agents of respiratory tract disease (5). To determine the prevalence of WUPyV and KIPyV in the plasma of HIV-1–infected patients, we screened 62 persons who were HIV-1 positive by using PCR to detect the 2 viruses. We also conducted phylogenetic analysis of the identified strains.
Highlights
2 novel polyomaviruses, KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV), were identified in the respiratory secretions of children with signs of acute respiratory signs [3,4]; little evidence exists to suggest that these viruses are causative agents of respiratory tract disease [5]
KIPyV and WUPyV have been detected in respiratory secretions and stool and serum specimens from pediatric patients with acute respiratory symptoms and have been found in respiratory tissue of adults and children [3,4,6,8]
Molecular analysis of the KIPyV and WUPyV identified in plasma showed that these polyomaviruses were not closely related to strains identified previously in other countries nor to the KIPyVs and WUPyVs identified in Italy in stool, respiratory tract tissue, and tonsils
Summary
KI and WU Polyomaviruses in Patients Infected with HIV-1, Italy 2 novel polyomaviruses, KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV), were identified in the respiratory secretions of children with signs of acute respiratory signs [3,4]; little evidence exists to suggest that these viruses are causative agents of respiratory tract disease [5]. To determine the prevalence of WUPyV and KIPyV in the plasma of HIV-1–infected patients, we screened 62 persons who were HIV-1 positive by using PCR to detect the 2 viruses.
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