KF/CP Nanoparticles Promoted Three Component Green Synthesis of Chromene Derivatives

Abstract

In this research work, was utilized green process for the synthesis of chromen derivatives is illustrated using one-pot reactions of anthranilic acid, 2-hydroxyacetophenone or its derivatives and dimethyl carbonate in the vicinity of catalytic amount of KF/Clinoptilolite nanoparticles in water as green solvent at 80 °C in short time. This procedure that is described here have some advantages such as short time of reaction, simple and green procedure, using low-cost catalyst, generation of product with excellent yield and employing various substrate for doing these reactions. Highlights Among heterocyclic compounds, chromene derivatives are important compounds with biological property for instance anticancer, anti-inflammatory, antimicrobial, antihyperglycemic and antineurodegenerative disorders similar to Alzheimer’s, Parkinson illness. The present methodology avoids the use of toxic catalyst. Also, chromenes are one of the imperative heterocyclic compounds that are seen broadly in plant, microorganisms and animals. This recoverable catalyst makes this protocol attractive and useful as an eco-safe catalyst with high yields of products.