Abstract
Objective: Cancer cells exhibit an elevated glycolytic phenotypeunder aerobic conditions, which is known as the Warburg effect.Recent studies have also shown that cancer cells are glucosedependentand cannot use ketone bodies as a primary source ofenergy. In this study, we have investigated the effects of ketonebodies on viability of breast cancer cells considering that breastcancer cells would not use ketone bodies as a primary energysource.Materials and Methods: In this study we have used MCF-7cells, which are breast cancer cells that cannot use ketone bodiesas a primary energy source and human foreskin fibroblast cells(HFF) as controls. We measured cell viability in both cells culturedin the presence or absence of glucose as well as the ketone bodiesacetoacetate and beta-hydroxybutyrate.Results: Cell viability was significantly decreased in responseto ketone bodies compared with control media in MCF-7 cellswhereas in control cells (HFF) cell viability was not changed.Conclusion: In light of the data obtained, we suggest thatdietary manipulation with the use of ketone bodies may be a newtherapeutic strategy for breast cancer.
Published Version
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