Abstract
Epilepsy is a prevalent neurological disorder that afflicts about 1% of the US population. Despite intensive research and development, antiepileptic drugs (AEDs) are largely unable to manage seizures in many patients with epilepsy. As an alternative to AEDs, diet therapies can be effective in controlling seizure susceptibility in humans. Our research illustrates that both the ketogenic diet and caloric restriction reduce seizure susceptibility in young and adult EL mice, a model for idiopathic generalized epilepsy. A concurrent reduction in circulating glucose levels and elevation in circulating ketone body levels associate with therapeutic efficacy.
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