Abstract
Shahida* and Muhammad Imran Qadir Author Affiliations Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Pakistan Received: September 17, 2020 | Published: September 28, 2020 Corresponding author: Shahida, Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Pakistan DOI: 10.26717/BJSTR.2020.30.004999
Highlights
Keratoconous is derived from Greek word “Kerato” means cornea and “conus” means cone
It is a non-inflammatory eye disorder linked to the progressive thinning of corneal stroma, asymmetrical corneal distortion and protrusion
Headache, photophobia, monocular diplopia and glare are some of the symptoms associated to keratoconous
Summary
Majority of Keratoconous cases are sporadic, which did not have any family history. First degree relatives who suffered from Keratoconous have 15 to 67 times higher risk of developing keratoconous than normal population. It is a complex non Mendelian disease. 5 to 10 % of patients have positive family history. Mutation in MIR184 gene has been found to cause keratoconous, but the majority of mutation still remains to be identified. In such case both autosomal dominant and recessive pattern of inheritance have been observed [5,6]
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