Abstract
Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA). It is characterized by a progressive peripheral expansion and central healing leaving atrophic scar. It is sometimes confused with squamous cell carcinoma (SCC) both clinically and histopathologically. We here report a case of KCM over the extensor aspect of the right forearm in a 57-year-old man with an abnormal looking scar.
Highlights
Keratoacanthoma (KA) is a rare benign epidermal tumour, usually diagnosed clinically, and histopathological examination confirms the diagnosis
Histopathological examination of a skin biopsy specimen from the raised margin revealed a huge pitcher like crater extending symmetrically across the upper dermis surrounded by epidermis on all sides (Figure 2)
squamous cell carcinoma (SCC) develops from normal epidermal keratinocytes, but KA is derived from the supraseboglandular parts of hair follicles [6]
Summary
Keratoacanthoma (KA) is a rare benign epidermal tumour, usually diagnosed clinically, and histopathological examination confirms the diagnosis. Most lesions are classical solitary but few unusual rare variants are described. Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of solitary KA with a clinical course of centrifugal expansion and central restitution or scarring [1]. The cause is unknown but proposed association with UV radiation, chemical exposure, and viral infection has been reported [2].
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