Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge

Abstract

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA) possessing several characteristics distinguishing it from typical KAs. Clinical presentation deviates from common KAs with lesions that continually expand peripherally.1, 2, 3 KCM also deviates from the usual histologic findings with a lack of some classic KA features. This is probably attributable to sampling issues given the size of the lesions and the limited capacity of a biopsy. Because of its rarity and lack of distinctive histopathologic features, KCM poses a difficult diagnostic challenge to clinicians and pathologists. Excellent communication and collaboration between the clinician and the pathologist is crucial for the correct and timely diagnosis, allowing for quick and proper treatment of the patient.