Katarakt Cerrahisi Sonrası Oküler Yüzey İnflamasyonu ve Kuru Göz Hastalığı Tedavisinde Dekspantenol/Sodyum Hyaluronat Fiks Kombinasyonuna Karşı Sodyum Hyaluronat Damla Etkinliği: Karşılaştırmalı Çalışma

Abstract

Objective: To compare the efficacy of dexpanthenol/ sodium hyaluronate fixed combination with sodium hyaluronate eye drops in the treatment of dry eye disease (DED) and ocular surface inflammation (OSI) following cataract surgery. Material and Methods: Sixty-three patients who underwent cataract surgery were included in this study. In addition to the standard postoperative treatment, one group (study group, n=30 eyes) received dexpanthenol/sodium hyaluronate fixed combination eye drops, while the other group was given sodium hyaluronate eye drops (control group, n=33 eyes). The 2 groups were compared in terms of best-corrected visual acuity, tear break-up time (TBUT), corneal flourescein staining, ocular surface disease index (OSDI) and in vivo confocal microscopy (IVCM) findings. Results: While TBUT was significantly greater in the study group than the control group (11.2, 8.9, respectively), corneal floresein staining (0.13, 0.48, respectively) and OSDI (10.8, 17.1, respectively) were significantly lower in the study group compared to the control group at postoperative 4 months. In IVCM, the number of dendritic cells and activated keratocytes were significantly lower in the study group (40.8, 13.9 respectively) compared to the control group (51.2, 18.0, respectively). In addition, while the total number of nerves in the study group (4.57) was higher than that of the control group (3.91), the nerve tortuosity was lower in the study group (1.57, 2.18, respectively). Conclusion: Dexpanthenol/sodium hyaluronate fixed combination eye drops could be preferred as an adjuvant for the treatment of DED and OSI following cataract surgery.