Abstract

SUMMARYBoth numerical and structural chromosome abnormalities were found in carcinomatous effusions. Large dispersion of the chromosome numbers around the mode, small percentage of modal cells, and karyotype instability, were characteristics of the malignant cells. In every tumor, however, the variations were made around a basic pattern (stemline karyotype), consistent with a clonal origin for all cells of the tumor. Both ordinary polyploidy and endoreduplication represented mechanisms responsible for the cell gigantism found in tumors. The absence of chromosomal abnormalities in benign effusions makes the cytogenetic analysis of sediments a valuable tool for the differential diagnosis of malignancy in cavitary effusions.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.