Abstract
Kainate (0.62–5 mM) was found to increase the initial rate of influx of 45Ca and of 22Na into the non-inulin space of rat thin brain cortex slices incubated in vitro, and to shorten the equilibration time for both these ions. N-methyl- dl-aspartate (50–1000 μM), l-glutamate (0.62–5 mM), dl-homocysteate (0.62–2.5 mM), and ibotenate (6–170 μM) also significantly increased the influx of 45Ca into the non-inulin space of this preparation, while the non-neurotoxic acidic amino N-acetyl- l-aspartate, and α-methy- dl-aspartate (both 1.25–5 mM), did not increase such influx. We suggest that enhanced calcium uptaje may represent the basis for the neurotoxic effects of these compounds.
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