Abstract
Increased emphasis on integrated pest management programs (IPM) has mandated that more selective insect control chemicals will be needed in successful implementation of these programs. Insect control by compounds with anti-juvenile hormone (AJH) activity would fit well into IPM for reasons of insect specificity. The last decade has seen the discovery of several types of AJH's, none of which however showed sufficient activity to warrant practical development. The bisthiocarbamate (I) and the two aryl thiocarbamates (II, III) described here have shown unexpected AJH activity in Manducasexta. Compound I shows mixed JH agonist/antagonist effects. Although compound I has shown only weak invivo AJH activity, evidence has been provided that it may exert its action via disruption of biosynthesis of JH in the corpusallatum. This mode of action might be further exploited by discovery of more potent compounds of related structural types.
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