Abstract
The ability of three anti-juvenile hormones and one juvenile hormone analogue to reduce in vivo juvenile hormone levels in Manduca sexta has been investigated. Two compounds. FMev (tetrahydro-4-fluoromethyl-4-hydroxy-2 H-pyran-2-one) and ETB (ethyl-4-[2-( tert-butylcarbonyloxy)butoxy]-benzoate) reduced the titres of juvenile hormones I and II to near the levels of detection in topically treated larvae. Precocene III (7-ethoxy-6-methoxy-2,2-dimethylchromene) was inactive but the juvenile hormone analogue hydroprene was as effective as the two anti-juvenile hormones in reducing endogenous juvenile hormone titres in larvae. FMev was also shown to reduce the level of juvenile hormones II and III in pharate adults.
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