Joint glucocorticoid clinical analysis of initial treatment of Kawasaki disease

Abstract

Objective To investigate the advantages of glucocorticoid combined with traditional methods and to explore glucocorticoid use in appropriate time in the whole course of the disease and the appropriate dose. Methods With reference to Kawasaki disease(KD)diagnostic criteria, 363 cases of patients with KD were enrolled, and divided into conventional treatment group and combined hormone group randomly.Combined hormone group according to clinical manifestations can be divided into sub groups as typical KD and atypical KD group.We analyzed respectively before and after 1 week treatment in two groups of children with the onset of age, gender, heating duration after treatment, IVIG treatment time, hospitalization days and total hospitalization expenses, tips and course of acute stage, recovery period the relevant indexes to the test, and coronary artery lesion(CAL)in one month. Results Thermal process after treatment, hospitalization duration and hospitalization expenses decreased significantly in combined hormone group compared with conventional treatment group.The difference between the two, in the clinical laboratory indexes and CAL have no obvious difference.In different types of KD, the thermal process after treatment, hospitalization days and hospitalization expenses, have decreased significantly in typical KD sub group when treating with combined hormone therapy comparing with hormone therapy atypical sub group.Other clinical laboratory indexes and CAL have no obvious differences in compared between the sub groups. Conclusion Combined hormone therapy for KD patients, plays an important role in shortening the thermal process after treatment and reducing the hospitalization expense. Key words: Kawasaki disease; Glucocorticoids; Intravenous gamma globulin