Abstract
BackgroundCombined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia.MethodsA total of 394 male subjects were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia was conducted.ResultsFor men with Mt5178C, alcohol consumption was significantly and negatively associated with the risk of hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol ≥ 140 mg/dl) (P for trend = 0.015). After adjustment for age, body mass index (BMI), habitual smoking, coffee consumption and use of antihypertensive medicine, the odds ratio (OR) for hyper-LDL cholesterolemia was significantly lower in daily drinkers with Mt5178C than non-drinkers with Mt5178C (OR = 0.360, 95% confidence intervals: 0.153-0.847). A significant and negative association between alcohol consumption and serum LDL cholesterol levels was also observed in Mt5178C genotypic men (P for trend < 0.01). On the other hand, the association between Mt5178A genotype and risk of hyper-LDL cholesterolemia does not appear to depend on alcohol consumption.ConclusionsFor Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.
Highlights
Mitochondrial DNA 5178 (Mt5178) C/A polymorphism, known as NADH dehydrogenase subunit-2 237 (ND2-237) Leu/Met, is a longevity-associated mitochondrial DNA polymorphism [1,2,3]
There have been no reports on the association between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol intake on the risk of dyslipidemia, which is clinically important for the prevention of atherosclerotic diseases [13]
Significant and negative associations between alcohol consumption and the risk of hyper-low-density lipoprotein (LDL) cholesterol were observed in Mt5178C genotypic men (P for trend = 0.015 and adjusted P for trend = 0.014, respectively)
Summary
Mitochondrial DNA 5178 (Mt5178) C/A polymorphism, known as NADH dehydrogenase subunit-2 237 (ND2-237) Leu/Met, is a longevity-associated mitochondrial DNA polymorphism [1,2,3]. Alcohol consumption is negatively associated with serum triglyceride levels in healthy male subjects with Mt5178A and with serum low-density lipoprotein (LDL) cholesterol levels in those with Mt5178C [11]. Previous studies have reported the joint effects of Mt5178 C/A polymorphism and alcohol intake on the risk of hypertension or hyperuricemia in middleaged Japanese men. For men with the Mt5178C genotype, daily alcohol consumption may increase the risk of hypertension [4] or hyperuricemia [12]. There have been no reports on the association between Mt5178 C/A polymorphism and alcohol intake on the risk of dyslipidemia, which is clinically important for the prevention of atherosclerotic diseases [13]. Combined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia
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