Jieguyao pills combined with platelet-rich plasma in treatment of femoral neck fracture

Abstract

Objective To observe the clinical efficacy of Jieguyao pills combined with autologous platelet-rich plasma (PRP) in the treatment of femoral neck fracture. Methods From Jan. 2015 to Dec. 2016, 90 patients with femoral neck fracture were randomly divided into three groups, 30 cases for each group. After being treated with closed reduction and hollow screw internal fixation, group A were treated with jieguyao pills, group B with PRP, and group C with Jieguyao pills and PRP. The fracture nonunion rate, femoral head necrosis rate, and Harris hip function score in the three groups were followed up and recorded. Results After the operation, the rates of nonunion and femoral head necrosiswere significantly lower in group C (3.33% and 3.33%) than in group A (26.67% and 30.00%) and group B (26.67% and 26.67%) , with statistical differences (all P<0.05 ) . Nine months the after operation, the Harris hip score and excellent rate were significantly higher in group C [(86.67±7.59) and 86.67%] than in group A [(78.20±11.37) and 53.33%] and group B [(80.27±9.73) and 63.33%], with statistical differences (all P<0.05 ) . Conclusion After closed reduction and internal fixation for femoral neck fracture, the combination of Jieguyao pills and PRP can obviously promote the fracture healing, reduce complications, and improve the patients’ function of hip joint and the quality of life. Key words: Femoral neck fracture; Platelet-rich plasma; Jieguyao pills; Harris hip function score