Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease secondary to JC polyomavirus which rarely involves the spinal cord. Limited evidence suggest mirtazapine¬ may be effective treatment. We present a 38 year-old man on natalizumab for multiple sclerosis presenting with acute asymmetrical lower limb weakness, who was subsequently diagnosed with PML with transverse myelitis and successfully treated with mirtazapine.
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