Abstract
We present fluorescent Janus hydrogel microbeads for continuous glucose sensing with pH calibration. The Janus hydrogel microbeads, that consist of fluorescent glucose and pH sensors, were fabricated with a UV-assisted centrifugal microfluidic device. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose within various pH conditions. As a proof of concept, we succeeded in obtaining the accurate value of glucose concentration in a body-fluid-like sample solution. We believe that our fluorescent microbeads, with pH calibration capability, could be applied to fully implantable sensors for continuous glucose monitoring.
Highlights
Continuous glucose monitoring (CGM) has been gaining attention, since it enables people with diabetes to constantly monitor blood glucose concentration [1]
The pH value obtained from the pH-sensing hemisphere can be used based on the reported methodwith involving for calibrating thepreviously obtained glucose concentration the fluorescence intensity of the [15]
We succeeded in fabricating glucose sensor microbeads with pH calibration by using a Janus structure
Summary
Continuous glucose monitoring (CGM) has been gaining attention, since it enables people with diabetes to constantly monitor blood glucose concentration [1]. Most commercial CGM devices are semi-implantable [2,3]. They need to inject sensing needles under the skin and attach a needle-connected transmitter onto the skin [4]. These CGM devices can measure glucose concentration accurately, the open wound and the wearing of the device in daily life can sometimes increase the risk of potential infection [5] and the burden for the patients [6]. The wired connection of semi-implantable devices is not favorable for patients’ physical activities [7]
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