Abstract
Polyethylene glycols (PEGs) and the structurally related polysorbates (PEG sorbitans—PEG molecular weight, 880-1056 g/mol) are excipients commonly used in small-molecule pharmaceutical drugs, as well as in some vaccines and most mAbs. Although polysorbates are common excipients in many vaccines, there is only a single case of vaccine anaphylaxis attributed to polysorbate 80 in a recent literature review.1,2 Similarly, the literature contains only a few cases of convincing skin test–confirmed immediate hypersensitivity to polysorbate 80 in mAbs, disinfectant solutions, intraarticular depot-steroids such as methylprednisolone acetate and triamcinolone acetonide, dexamethasone-lidocaine preparations for intramuscular and intraarticular injection (in Europe and some other countries), and subcutaneously injected erythropoietin.
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