Abstract
Here we report a colorimetric cytosensor for osteosarcoma CTCs based on mesenchymal marker cell surface vimentin monoclonal antibody 84-1 (mAb 84-1) and jaboticaba-inspired signal amplification. The linear range of our cytosensor ranges from 50 to 1.0 × 106 cells/mL and the limit of detection is 18 cells/mL for the human osteosarcoma cell line. The cytosensor also exhibits good selectivity for epithelial- derived cancer compared to mesenchymal-derived sarcomas, and has been successfully applied to detection CTCs in blood from osteosarcoma patients. In summary, an accurate, sensitive, and controllable colorimetric sensing platform has been developed, with promise for the early diagnosis and prognostic of osteosarcoma.
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