J0440303 マイクロバブルから直接作るシアノアクリレート中空微粒子に関する研究([J044-03]ソフトマター・イノベーション(3),機械材料・材料加工部門)

Abstract

Hollow microparticles, whose core material is in a gaseous state, have advantageous features such as thermal and acoustic insulation, and lightweight. Due to their inherent acoustic property, the biocompatible hollow microparticles of less than 5 μm are also used in medical applications (e.g., as ultrasound contrast agents and drug carriers of drug delivery systems). Especially, hollow microparticles of less than 1 μm can through the blood vessel wall of cancer cell, and are expected to be available for cancer treatment such as capture of tumor and destruction of cancer cell. Recently, a novel fabrication method of hollow microparticles was developed, which can be fabricated by just blowing the cyanoacrylate vapor as microbubbles. In this study, we fabricated the cyanoacrylate hollow microparticles of less than 1 μm with changing the pH value of aqueous dispersion and tested the effect of supply gas to cyanoacrylate hollow microparticles fabrication.