Abstract
Tissue engineering is an alternative approach for the preparation of small-diameter (4-6 mm) vascular grafts due to the potential to control thrombosis, anastomotic cellular hyperplasia and matrix production. Then, in order to make three-dimensional structure, many researches using scaffold have been done. However, scaffold has some problems to make prominent Tissue engineered blood vessels (TEBVs). For example, they are degradation characteristic and mechanical properties, disturbance of interaction between cells. Therefore, we constructed novel Scaffold-free model of TEBVs which does not use scaffold, and we produced TEBVs by using this Scaffold-free model. Moreover, we promoted differentiation of stem cells by cultivating with mechanical stimulus, and we evaluated this result. Also, we evaluated cell differentiation when this model is cultured by not pulsatile flow only radial stress.
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