Abstract
Osteon is a fundamental unit of cortical bone. Osteons are elongated cylindrical structure and the directions are generally aligned with axis of long bone. It is considered that BMU movement leads to elongation of osteons. However, the reason why BMU moves along the axis of long bone remains unclear. In this study, from mechanical standpoints, we propose mathematical models of trabecular and osteonal remodeling combining mechanosensing and signaling systems, and analyze BMU movement in trabecular and osteonal remodeling. We found that continual resorption on the surface of high RANKL concentration, resulting from low stress, leads to BMU movement.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Proceedings of Mechanical Engineering Congress, Japan
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
