Abstract
The first synthetic genetic circuits to use analog computation have been developed. These circuits involve fewer components and resources, and can execute more complex operations, than their digital counterparts. See Letter p.619 The design of novel genetic control systems for synthetic biology is dominated by digital logic. This is necessarily a complex arrangement. Now Timothy Lu and colleagues have harnessed analog building-blocks found in natural cells to perform arithmetic operations in the logarithmic domain. Such analog circuits — which could be integrated with digital — should make it possible to use fewer components to implement complex computations that require wide dynamic range in biosensing.
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