Issue Cover (September 2020)

Abstract

Journal of NeurochemistryVolume 154, Issue 6 Issue CoverFree Access Issue Cover (September 2020) First published: 11 September 2020 https://doi.org/10.1111/jnc.14761 Read the full article: ‘Enteric short-chain fatty acids promote proliferation of human neural progenitor cells’ by L. L. Yang, V. Millischer, S. Rodin, D. F. MacFabe, J. C. Villaescusa, C. Lavebratt, (J. Neurochem. 2020, vol. 154 (6), pp. 635–646) on doi:10.1111/jnc.14928 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Front cover: Short-chain fatty acids (SCFAs) in the human body are produced mainly by anaerobic bacteria in the gut from their fermentation of dietary fibers. SCFAs have been reported to be key mediators in the communication between the gut and the brain. Multiple effects of the SCFAs on the nervous system have been shown, including regulation of microglial maturation and activation and of embryonic stem cell differentiation into neural cells. However, the effect of SCFAs on early human neural cells is unknown. Results show that SCFAs at physiological levels increased the proliferation of human neural progenitor cells, generated from a human embryonic stem cell line (HS980). This finding proposes that SCFAs can regulate early human neural system development, which might be relevant for a putative ‘maternal gut-fetal brain-axis’. Image content: Immunofluorescence staining image of human neural progenitor cells with Nestin (red), ZO-1(green) and DAPI (blue), showing neural rosettes, tight junctions and nuclei. Read the full article ‘Enteric short-chain fatty acids promote proliferation of human neural progenitor cells’ by L. L. Yang, V. Millischer, S. Rodin, D. F. MacFabe, J. C. Villaescusa, C. Lavebratt, (J. Neurochem. 2020, vol. 154 (6), pp. 635–646) on doi:10.1111/jnc.14928 Volume154, Issue6September 2020 RelatedInformation