Abstract
Front cover: Positron Emission Tomography (PET) image of mGluR5 density in rat brain, acquired with the novel fluorine- 18 labeled tracer [18F]PSS232. The metabotropic glutamate receptor 5 (mGluR5) is involved in the regulation of synaptic plasticity and modulation of neural network activity. The density of mGluR5 is altered in various psychiatric and neurological disorders. Shown is a PET image of a rat brain (coronal, Bregma ~0 mm) after intravenous injection of 37 MBq [18F]PSS232, a fluorine- 18 labeled analogue of [11C]ABP688. Labeling with 18F instead of 11C bears the advantage of a longer physical half-life and improved PET imaging logistics. PET data was acquired on an Argus PET/CT scanner (Sedecal, Spain) and superimposed on an MRI T2 template (PMOD, Switzerland). Red indicates highest radioactivity accumulation, i.e., highest mGluR5 (striatum), blue indicates lowest radioactivity. J. Neurochem. 2015, vol. 133 (3), pp. 330–342. Read the full article on doi: 10.1111/jnc.13001
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