Abstract
Journal of NeurochemistryVolume 150, Issue 3 Issue CoverFree Access Issue Cover (August 2019) First published: 26 July 2019 https://doi.org/10.1111/jnc.14516 Read the full article: ‘Hyaluronan synthesis supports glutamate transporter activity’ by M. K. Hayashi, T. Nishioka, H. Shimizu, K. Takahashi, W. Kakegawa, T. Mikami, Y. Hirayama, S. Koizumi, S. Yoshida, M. Yuzaki, M. Tammi, Y. Sekino, K. Kaibuchi, Y. Shigemoto-Mogami, M. Yasui, K. Sato (J. Neurochem. 2019, vol. 150 (3), pp. 249–263) on doi: 10.1111/jnc.14791 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Front cover:At excitatory synapses, glutamate is removed by glutamate transporters to turn off the signal and prevent excitotoxicity. Hyaluronan is synthesized, secreted, and anchored by hyaluronan synthases (HAS) at the plasma membrane. Cellular process localization of glutamate transporters is hyaluronan synthase dependent, while a major hyaluronan receptor CD44 is not necessary. Hyaluronan synthesized by hyaluronan synthase interacts with glutamate transporters and supports glutamate uptake. Our findings reveal that hyaluronan synthesis helps to turn off excitatory signals. Image Content: Confocal microscopy image of an astrocyte in CD44 knockout mice primary culture. mEGFP-labeled glutamate transporter GLT1 (green) localizes to astrocyte cellular processes. Lck-mCherry labels cellular membrane (magenta). Read the full article ‘Hyaluronan synthesis supports glutamate transporter activity’ by M. K. Hayashi, T. Nishioka, H. Shimizu, K. Takahashi, W. Kakegawa, T. Mikami, Y. Hirayama, S. Koizumi, S. Yoshida, M. Yuzaki, M. Tammi, Y. Sekino, K. Kaibuchi, Y. Shigemoto-Mogami, M. Yasui, K. Sato (J. Neurochem. 2019, vol. 150 (3), pp. 249–263) on doi: 10.1111/jnc.14791 Volume150, Issue3August 2019 RelatedInformation
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