Abstract
Isaacs’ syndrome (IS), also known as acquired neuromyotonia, is a rare neuromuscular disease, manifested by involuntary continuous motor activity.1 Although there are reports in children,2,3 IS is more frequent in adults.1 The clinical presentation can include muscle cramps, fasciculations, myokymia, and pseudomyotonia. Electromyography (EMG) remains the gold standard for diagnosis.1,4 Dysfunction of peripheral nerve voltage-gated potassium channels (VGKC) appears to be related to the development of the disease.1,3,4,5 Paraneoplastic factors also play an important role in IS.5 Anticonvulsants are the first therapeutic option.1,4,5
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call